Pharmaceutical parenteral closures demand the best
cleaning possible.
The DIRECT IMPACT CLEANING with high pressure
wash and rinse
sprays insures removal of particles, manufacturing soils,
chemical contamination
and pyrogens. The result is total cleaning of all
surfaces including recessed
blind holes which retain water, particulates
and silicone (from
pre-siliconization by stopper manufacturer) due to
capillary action. The entire outer drum surfaces are cleaned so that
all
silicone and particulates go to drain.
Contamination of stoppers BEFORE
treatment
Contamination of stoppers a
AFTER treatment
The DIRECT IMPACT CLEANING guarantees
that the
required shearing action is applied to dislodge the pyrogens
off the stoppers.
It also insures that the stoppers are individually
flushed clean and the
particles are drained. This process is repeatable
and gives fully validatable
results.
A detailed technical animation of the
HUBER System process
is available upon request.
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